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[PubMed] [JAMA] Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR

Benefits Outweigh Temporary Fatigue Despite initial tiredness, GLP-1 medications provide significant benefits in managing blood sugar and supporting weight loss

doi:10.1016/j.tem.2020.02.006 26

Preclinical research indicated that that GLP-1 RAs attenuate dopamine release, consequently reducing cravings and compulsive drug-seeking behaviors (13, 16, 17)

So Nancy "started to drop hints" that maybe they, too, should try the medications that had been such a boon to her

This represents a personal decision about risk tolerance that each individual must make for themselves