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Treatment with ACE inhibitors has been shown to offer protection against the loss of DA neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal models (100, 101), as well as the 6-hydroxydopamine (6-OHDA) rat model (102)

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In 2015, the EFSA released B12 recommendations that considers the research published since the 1998 IOMs recommendations (EFSA, 2015

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