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Practical scenarios: when alternating might make sense Despite the limitations, there are specific situations where alternating between semaglutide and tirzepatide could be a reasonable approach

It is likely that the fluid retention is due to another underlying cause, in which case decreasing water intake would not help and may even cause further harm

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While direct head-to-head comparisons in randomized clinical trials are limited, real-world evidence and observational studies help supplement the lack of direct head-to-head clinical trial data, offering important context for clinical decision-making

They do not necessarily mean the drug has stopped working

and change-from-baseline values, that were calculated by subtracting baseline measurements from the last follow-up day measurements