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The pattern is important: most gastrointestinal side effects are mild to moderate, occur in the early weeks of each new dose, and improve as the body adapts
A second trial in healthier, community-dwelling older adults showed less dramatic effects, suggesting the intervention may provide more benefit to those who already show measurable deficiency and metabolic stress
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[19] Symptoms of chronic intoxication include insomnia, irritability, change in personality, and psychotic symptoms that may be clinically indistinguishable from other psychotic disorders, like schizophrenia
Multivariate analysis of metabolomics data by PCA Quantitative changes in metabolites between the three groups were evaluated using principal component analysis (PCA) as an unsupervised multivariate statistical analysis approach ( Fig 2 )
