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As of July 26, 2026, 21 CFR 216.23 lists six substances that can be used through this pathway: Brilliant Blue G, cantharidin for topical use only, diphenylcyclopropenone for topical use only, N-acetyl-D-glucosamine for topical use only, squaric acid dibutyl ester for topical use only, and thymol iodide for topical use only

Therapeutic Advances in Endocrinology and Metabolism, 16

Dec 2014;20(12):1371-1375

Enhances insulin secretion and sensitivity

Its skin-lightening properties help to reduce hyperpigmentation and dark spots, leading to a more even skin tone

Adjusting protocols based on response Inadequate response troubleshooting: Verify consistent administration and proper dosing