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Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space
doi: 10.1053/j.gastro.2016.09.062 5
The Verdict: May offer short-term appetite effects, but unlikely to provide significant weight loss when used alone
The trial, extended for 2 years, found that completers maintained a 7.8 kg weight loss from baseline [15]
Wikberg JE, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A
J., Nishiyama, H., Wiese, R
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