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However, most treatments offer temporary rather than long-term relief

Caffeic acid also maintains genome integrity by protecting DNA from oxidative damage, while flavonoids increase electron delocalization through conjugated -systems and oxo-groups, which optimize radical scavenging ability (119)

Saunders, Philadelphia, pp 12751316 McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M et al (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete

"Essential" means your body cannot produce it on its own

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This reduces bioavailability