My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it
One older study on Byetta (exenatide) showed minimal transfer, but there are no studies on semaglutide, tirzepatide, or liraglutide in breast milk, and no data on infant outcomes when exposed via breast milk
151,152 Additionally, GLP-1 RAs lower oxidative stress within the brain, suggesting neuroprotective benefits that could improve neural health and hinder age-related deterioration
Peptide Profile Peptide Name: Melanotan II Main Function: Known for stimulating melanogenesis, leading to increased skin pigmentation or tanning
PMID 22006024
Beauty and nutrition have become inextricably linked: We keep hearing "beauty from the inside out," in reference to dietary impact on physical appearance and health