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As a permanently charged quaternary cation it is water-soluble and does not require organic cosolvent for aqueous work, though DMSO stocks are common in cell-based screens
Anecdotally, benzyl alcohol also has a mild local anesthetic effect
Placebo-controlled trial
A commonly extrapolated human-equivalent dose is roughly 2 to 10 micrograms per kilogram, though no human dose-ranging trial has been completed or published
Use a hard and fast approach when pushing the needle (bevel and shaft) into the skin, going in at a 90 degree angle (see video below)
The recognised reasons above, particularly the shift in potassium and the body adjusting to corrected levels, explain the symptoms without needing a detox theory
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