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Mechanisms of action and therapeutic application of glucagon-like Peptide-1
Diabetes GLP-1s perform better but still leak demand: Diabetes-indicated GLP-1s show higher retention (24% at one year) and face fewer access hurdles due to broader coverage and disease framing, yet 76% of demand remains unmet
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The pivotal STEP-1 trial reported approximately 14.9 percent mean body weight loss at 68 weeks on semaglutide
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