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Metabolism and Bioavailability Endogenous biosynthesis The synthesis of lipoic acid has been characterized in detail in the yeast Saccharomyces cerevisiae , but not all genes involved in the process have been identified in humans (5)

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Enzymatic antioxidants are localized in specific subcellular compartments where radicals are frequently generated (mitochondria, peroxisomes or microbodies, cell cytosol) or are present in the systemic circulation

Why delayed gastric emptying matters in anesthesia Pulmonary aspiration occurs when gastric contents enter the lungs during anesthesia, potentially leading to: Aspiration pneumonitis Acute respiratory distress syndrome (ARDS) Increased perioperative morbidity and mortality Standard fasting guidelines (e.g., 68 hours for solids) aim to minimize this risk