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The Journal of physiology, 532(Pt 2), 283

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Dose reduction may work for select patients, but complete discontinuation remains difficult without alternative therapies or a multidisciplinary approach

While further research is required to translate these preclinical findings into clinical practice, the identification of the GLP-1R/PPARG/ACSL1 pathway provides a clear roadmap for future investigations into the intersection of metabolic drugs and cancer immunotherapy in the future.

however, Y1-R agonism may also stimulate a reaction step in the glycolytic pathway