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Male C57BL/6 mice were randomly divided into three groups: low-fat diet, high-fat diet and high-fat diet plus 5% MDG-1, gene microarray analysis and reverse transcription-polymerase chain reaction (RT-PCR) showed that MDG-1 could inhibit PPAR, activate PPAR , up-regulate the expression of PPARs-related liver X receptor (LXR) and cholesterol 7-alpha hydroxylase (CYP7A1), and inhibit the level of sterol regulatory element-binding protein-1 (SREBP-1c) to accelerate cholesterol intake and excretion (84)
About 85-95% is bound to ceruloplasmin
10.1016/j.cell.2008.06.016 Cell 26 PatelN
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