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This depletion was significantly correlated with insulin resistance, as measured by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) index ( Obesity-induced IR correlates with increased DA depletion in the striatum and substantia nigra, and additionally, it can affect both the postsynaptic DA receptor and presynaptic DA transporter expression and function ( It is reported that pharmacological treatment of PD with DRT plausibly plays a role on glucose metabolism, with the finding that in animal model levodopa and DA can suppress glucose-dependent pancreatic islets secretion by reducing the frequency of intracellular calcium current oscillation, thus representing a DA-ergic negative feedback on insulin secretion ( 2.2 Clinical studies Curiously, an epidemiologic, large-scale, population-based study on 6,800,000 individuals from the database of the Korean National Health Insurance Service observed that being underweight may be a risk factor for the development of PD

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