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Phospholipase A2 is overactivated during SAP, destroying pulmonary surfactant and inducing inflammation through accumulation of eicosanoids and platelet-activating factor [105]
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SIRT5 functions as a global regulator of mitochondrial lysine succinylation and involved in metabolic regulation [124]
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Maintaining GSH is vital for oxidation-reduction processes and for detoxifying hydrogen peroxide and organic peroxides produced by inflammation in cells
Figure 2 Animal experiments have demonstrated that acute tryptophan depletion reduces brain tryptophan concentration by 70%, leading to decreased serotonin levels, diminished 5-HT receptor binding (236, 237), and effects on compulsive behavior (238)
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