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Still, tirzepatide was linked to fewer reported side effects overall
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Martinelli-Klay CP, Laporte ML, Martinelli CR, Martinelli C, Lombardi T
Within days to weeks of stopping treatment, patients generally experience return of appetite to pre-treatment levels, faster gastric emptying, and loss of the medication's effects on satiety signaling
By the end of the first week or into the second, most patients report a rebound in energy, feeling lighter and more vibrant as their bodies become more efficient at burning fat for fuel
NEJM (April 2025) Bottom line: This ongoing phase 3, multicenter, randomized, double-blind, placebo-controlled trial assigned 1197 patients with biopsy-defined metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis stage 2 or 3 to receive either semaglutide 2.4 mg once-weekly or placebo for 240 weeks
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