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This dual-hormone approach may become a new standard in obesity care
The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
Discussion and Clinical Perspectives GLP-1 receptor agonists have transformed obesity therapy by enabling sustained and clinically meaningful weight reduction
The transition requires planning because of the different onset profiles of these medications
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Obesity and weight management In recent years, GLP-1s like semaglutide and tirzepatide have been approved by the FDA at higher doses specifically for weight loss
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