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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial
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Different patients require different needs
Abbreviations AT: As-treated CEA: Cost-effectiveness analysis CPI: Consumer price index CVD: Cardiovascular disease GDP: Gross domestic product GLA: Glucose-lowering agent GLP-1RA: GLP-1 receptor agonist HR: Hazard ratio ICER: Incremental cost-effectiveness ratio ITT: Intention-to-treated MACE: Major adverse cardiovascular event NHI: National Health Insurance NHIRD: National Health Insurance Research Database NNT: Number needed to treat OOP: Out-of-pocket QALY: Quality-adjusted life year T2D: Type 2 diabetes WTP: Willingness-to-pay References American Diabetes Association
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