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As obesity is known to increase the risk of cardiovascular disease, including HF, therefore, anti-obesity interventions like tirzepatide may have cardioprotective effects [101]
In contrast, dietary d-carnitine intake reduced the acyl-carnitine concentration in the body and induced lipid accumulation in the liver, which was accompanied by lipotoxicity
Consequently, an effort has been made to review various plant-derived products possessing GLP-1 activating properties, specifically those acting as agonists on the GLP-1 receptor, which demonstrate interactions with both the catalytic site and the secondary binding site present in the GLP-1 receptor [8]
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