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& Barrand, M
This does not mean zero drug reaches CNS targets, but it does mean the fraction is likely small and the pharmacokinetic profile is poorly characterized for that route
Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma
References 1From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management | Yuan et al
If you specifically want fat loss with minimal other effects, AOD 9604 is cleaner
(Frontiers in Pharmacology, 2022) reports a half-life under 30 minutes after IM or IV administration in rodent and dog models, which is why split-dose schedules appear in the literature
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