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In one study of postmenopausal women, those on hormone therapy experienced greater weight loss with semaglutide than those not on HRT, possibly due to estrogens effects on metabolism and appetite regulation

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Lancet 402 , 627640 (2023)

The lead author owns a store called Reverse Skin Aging, which sells these peptides

Both share the GLP-1 class side-effect profile, led by gastrointestinal symptoms: nausea, vomiting, diarrhea, and constipation, worst during dose increases

This threshold is associated with meaningful health benefits including improvements in cardiovascular risk factors and glycemic control