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Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)
Arch Biochem Biophys 2008;478:136142
Week 4 Weight 23% from baseline or 7-day average clearly trending down Waist 23 cm Hunger/cravings by 23 points Week 8 Weight 5% or waist 46 cm Side-effects controlled at current dose Weeks 1224 Weight 710% HbA1c 0.51.0% if elevated at baseline Triglycerides and BP improving Lean mass preserved on DXA/BIA (thanks to protein + resistance training) Rate cap to protect muscle/skin: aim for 1% body-weight/week
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