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While dermatologic reactions are not among the most prominent adverse effects listed in the prescribing information, patients and clinicians have reported various skin-related symptoms during semaglutide therapy

Nearly all the excitatory mechanisms in the nervous system go into overdrive and, until new adaptations to the drug-free state develop, the brain and peripheral nervous system are in a hyperexcitable state, and extremely vulnerable to stress

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The STEP 1 trial found that nausea was reported by 44% of participants in the semaglutide group, but the vast majority of nausea episodes were transient and occurred during dose escalation

During dose escalation Dose escalation can temporarily increase injection site reactions