Another study comparing the efficacy between lycopene gel and Calendula officinalis gel for OLK showed that lycopene had similar effectiveness as the other gel, both of which significantly reduced the size of OLK (35)
Timing adjustments also matter significantly
Mar Drugs 13:62266246 Gatlin DM III, Barrows FT, Brown P, Dabrowski K, Gaylord TG, Hardy RW, Herman E, Hu G, Krogdahl , Nelson R (2007) Expanding the utilization of sustainable plant products in aquafeeds: a review
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This may bring about additional benefits, so long as an effective dose is still used
The volume drawn determines the final concentration (see dilution charts below)