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The FDA removed 12 substances from Category 2 effective April 22, 2026 because the nominations were withdrawn by the nominators, not because the FDA cleared anything removal does not place a substance in Category 1 or on the 503A bulks list, so these compounds now sit in no FDA category at all

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Treatments with DSIP and the DSIP-CBBBP fusion peptide significantly countered this reduction, showcasing their potential as therapeutic agents for modulating hedonistic behavior