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Hormonal Issues : Certain hormonal conditions, particularly those involving the adrenal glands can cause the skin and lips to turn darker
Wang S-M and Pae C-U
This is a different satiety circuit than the hypothalamic pathway engaged by GLP-1 agonists
Its efficacy has been supported by several studies: Antioxidant Benefits: Polypodium reduces oxidative stress, a key factor in melasma, by neutralizing free radicals and minimizing inflammation caused by UV-induced skin damage
Circulation Research (2003) 93:2629
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