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Finally, Hsieh et al

Ortiz A, Minguet C, Gonzalo R, et al

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Typical course length in clinical practice is 8 to 12 weeks, after which a reassessment period is recommended

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Further, NASO B12 was well-tolerated throughout the treatment period.[] Patients on metformin therapy receiving NASO B12 should also be instructed that they will require weekly intranasal administration of NASO B12 spray in each nostril after correction of vitamin B12 deficiency for the remainder of their lives