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A similar protection against steatosis has been previously noted in GCLM KO mice challenged with other liver toxicants 38 or stress-inducing diets 17,39

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Metformin augments Anti-Inflammatory and chondroprotective properties of mesenchymal stem cells in experimental osteoarthritis

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This endogenous synthesis is crucial because it successfully crosses both cellular and mitochondrial membranes, delivering antioxidant protection exactly where the electron transport chain needs it most