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Adverse gastrointestinal events included pancreatitis, bowel obstruction, and gastroparesis

GLP-1(936) inhibits PKA activity by a G i/o -dependent mechanism The GCGR can activate both stimulatory (G s ) and inhibitory (G i/o ) GTP-binding proteins [33,34,35] and may therefore mediate the PTX-sensitive effects of GLP-1(936)

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