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In two head-to-head comparisons, a small, transient mean increase in HR from baseline was observed with lixisenatide

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The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size

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This proactive approach ensures that each patients plan remains optimized for their evolving needs, maximizing the therapys effectiveness