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Biguanide MC001, a dual inhibitor of OXPHOS and glycolysis, shows enhanced antitumor activity without increasing lactate production

The main considerations: seizure risk with bupropion in vulnerable patients, blood pressure effects (bupropion can raise BP slightly), and overlapping appetite suppression that can drive intake low

Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae

Eating, drinking, and sex all activate dopamine, a brain chemical linked to pleasure and motivation

Prevents Esophageal Damage : By quickly lowering acid levels, it protects the esophageal lining from chronic GERD, reducing risks of inflammation or ulcers

J Agric Food Chem 45:13381344