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In addition to the direct impact on the proportion of gut bacteria, GLP-1RAs were found to upregulate tight junction proteins in the intestinal mucosa, which helps prevent the translocation of bacteria to the blood
The GLP1-RAs class has grown in the last decade with several agents available for usein the market, Since the efficacy and tolerability, dosing frequency, administration requirements, and cost may vary between agents within the class, each agent may offer unique advantages and disadvantages
It can be used to prevent aging symptoms, enhance sleep quality, decrease body fat and water retention, strengthen the muscles, and improve overall wellness
Challenges Affordability: Taxes may disproportionately affect low-income families who rely on these affordable options
doi: 10.1056/NEJMe2312646 266 LewingtonSClarkeRQizilbashNPetoRCollinsRCollaborationPS
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