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The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes
Drug Discov Today Technol
Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning
PMCID: PMC8746815
It is studied for its extended half-life and enhanced bioavailability compared with native IGF-1
Findings are preliminary and have not been replicated in robust human trials
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