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With over 190,000 estimated worldwide patient treatments to date, the reported incidence of side effects is less than 0.4 percent, and these were minor

Some report improved sleep quality, possibly related to reduced pain allowing better rest

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Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , five times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3