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HGH injections create supraphysiological spikes followed by rapid decline Side effect profiles differ significantly: Published data shows secretagogues have milder side effects (injection site reactions, mild water retention) compared to HGH (joint pain, insulin resistance, potential organ enlargement at high doses) Regulatory status differs: HGH (somatropin) is FDA-approved for specific conditions

Phase 4: Beyond Week 16 This is maintenance and optimization

Knop FK, Aroda VR, do Vale RD, Holst-Hansen T, Laursen PN, Rosenstock J, et al

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Multiple studies have demonstrated cardiac-specific benefits: Improved left ventricular function in GH-deficient models (Bisi et al., 1999) Anti-fibrotic effects on cardiac tissue Protection against ischemia-reperfusion injury in isolated heart models (Locatelli et al., 1999) Reduced cardiomyocyte apoptosis following ischemic damage These cardiac effects appear to be mediated through CD36 receptor activation independent of GH release making Hexarelin unique among GHRPs

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