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A supplement strategy should not overlook: Adequate total protein Cysteine-containing foods such as poultry, eggs, dairy, legumes and meat Glycine from protein-rich foods, collagen and connective tissues Selenium from seafood, eggs, meat and selected plant foods Magnesium and B-vitamin adequacy Cruciferous vegetables and other foods that support endogenous antioxidant-response pathways Food does not always replace clinically appropriate supplementation, but poor protein and nutrient intake can undermine the pathway a supplement is intended to support

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The reduction in the area of the axons and the increase in the number of degenerated axons in Wfs1 KO animals optic nerves refers to neuropathological processes in which some axons are eliminated and some degenerate, which may happen prior to disappearance