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Tumors with HRD rely on alternative DNA repair mechanisms for survival, so agents that inhibit DNA single-strand break (SSB) repair or induce more SSBs trigger genomic instability and apoptosis 34
Although this approximation provides a good description for phenomena that do not depend on the spatial distribution of H 2 O 2 such as the average concentration of H 2 O 2 , in some cases a spatio-temporal model may be necessary
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