[1] Retatrutide (phase 2, 48 weeks): up to 24.2% mean weight loss on 12 mg, with curves still descending at study end
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The same paper also included a nested case-control component of 120,054 patients with T2DM followed for 7.4 years and observed a lower association between dementia and exposure to GLP-1RAs compared with other antidiabetics 39
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The bottom line Bupropion-naltrexone is an oral weight loss medication
These drugs work by boosting insulin (which lowers blood sugar), reducing a hormone called glucagon (which raises blood sugar), slowing down digestion, curbing appetite, and helping people lose weight