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A meta-analysis by Dodd et al
Methods Sixteen weeks old nulligravid female Wistar rats were housed at a constant temperature (22C) in a 12 hours light and dark cycle environment with free access to food and drinking water
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In LepR-deficient Koletsky rats, the adenovirally induced expression of LepRs in ARC nucleus improves peripheral insulin sensitivity via enhanced suppression of hepatic glucose production, with no change in insulin-stimulated glucose uptake or disposal
Dose increases beyond 12mg dont occur in current protocols because 12mg represents maximum studied dose, not because higher doses are needed
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