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The article says evidence suggests estrogen modulates GLP-1 receptor expression in hypothalamic appetite centres, so as estrogen falls, GLP-1 signalling efficiency may diminish and compound existing metabolic challenges
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If this dysfunction is not promptly blocked, it will eventually lead to cell damage and death (41)
10.1016/S0735-1097(22)02516-5 76
Some research indicates that blood levels can begin to rise significantly within the first week of daily use
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