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Epidemiology of Type 2 Diabetes Global Burden of Disease and Forecasted Trends

GLP-1R mRNA is most abundant in islets and lung with lesser amounts in the stomach

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Due to DPP-4 and renal clearance, native GLP-1 in humans has a half-life of about 1-2 minutes (21, 22, 89)

Consequently, it remains a highly relevant compound across obesity and energy homeostasis research disciplines