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These may include: A personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) A history of pancreatitis (depending on clinical evaluation) Pregnancy or breastfeeding Known hypersensitivity to GLP-1 medications or their ingredients Individuals with a history of mental health conditions, including depression or suicidal thoughts, should be carefully evaluated by a licensed healthcare provider before starting treatment

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Patients should temporarily discontinue metformin during acute illness, particularly if accompanied by vomiting, diarrhoea, or reduced oral intake, and seek medical advice

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Participants were eligible to be included in the trial only if all of the following criteria applied: Informed consent obtained before any trial-related activities