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Early studies indicated that brain regions of high FCD also had high glucose use, leading to a hypothesis that regions of high functional network activity, e.g

PMC 372417

Enhances nitric oxide production, which supports endothelial and kidney function

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Growth and apoptosis Ex-4 significantly improves the survival of rat cortical neurons under oxygen/glucose deprivation (OGD) conditions through reduced apoptosis rates, increased expression of glucose-regulated protein 78, and decreased levels of C/EBP-homologous protein, indicating the role of Ex-4 in modulating unfolded protein response for protecting neurons from ischemic damage [56]

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