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Additionally, a systematic review by Drant et al

(See Figure 1) FIGURE 1 2.2 Cisplatin induces oxidative stress The cochleas high metabolic rate results in its production of abundant reactive oxygen species (ROS), so it requires an active antioxidant defense system [glutathione (GSH), oxidized glutathione (GSSG), and antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR)] to achieve a dynamic oxidant-antioxidant balance to maintain healthy hearing

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These were more frequent and dose dependent with monlunabant compared with placebo

they are opening unprecedented commercial opportunities for suppliers, CDMOs, and regulatory-savvy manufacturers alike

It can take time for the mind to catch up with changes in the body