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Levels below 200 pg/mL suggest deficiency
Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)
The same molecular pathways that repair damaged tissue can theoretically support tumor growth
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Because the solution is bacteriostatic, one vial can support several reconstitutions across the life of a research project rather than being discarded after a single use
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