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Under physiological conditions, LRRK2 and PINK1 form a functional balance to maintain normal TH expression and DA synthesis in dopaminergic neurons [44]

4,5 Role of GLP-1 Receptor Agonists for Weight Loss Neuropsychiatric considerations Emerging reports indicate potential neuropsychiatric effects of GLP-1RAs, including mood changes, appetite suppression, and cognitive function implications

1 Thus, numerous studies have used biotechnology to extend the half-life of GLP-1 RAs, with strategies including amino acid sequence substitution, fatty acid conjugation with a linker, fusion of albumin or the IgG fragment crystallizable (Fc) region (Figure 1)

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