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In the STEP trials evaluating semaglutide for weight management in individuals without diabetes, participants demonstrated reductions in HOMA-IR alongside substantial weight loss
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Among these genes, some of them are associated with alterations of free radical formation or mitochondrial dysfunctions
This review sets out the molecular and central nervous system biology of the GLP-1 receptor, the mechanisms proposed to underlie its neuroprotective effects, and the clinical trial record in Parkinsons and Alzheimers disease
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