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The National Institute for Health and Care Excellence (NICE) notes that the prevalence of Vitamin B12 deficiency is approximately 6% in those under 60 years old, rising to 20% in the over 60s

2 One study looked at 4-hydroxyisoleucine in rats with an amyotrophic lateral sclerosis-like condition and found better movement and less oxidative stress and cell death through insulin-like growth factor 1 (IGF-1) and GLP-1 pathways, 101 Taken together, these findings suggest that targeting the GLP-1 signaling pathway might be a way to treat amyotrophic lateral sclerosis

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The difference between this and the original IGF-1 is that, instead of glutamic acid, LR3 contains arginine at the 3rd position of its amino sequence, notated in the R3 compenent

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