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Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging

Just how is that

Simultaneously, SAM levels rise due to reduced consumption by NNMT, supporting methylation reactions critical for DNA maintenance, epigenetic regulation, and neurotransmitter synthesis

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Intrinsic Factor and Absorption Challenges As previously noted, intrinsic factor is a key player in B12 absorption, as it binds to the vitamin, allowing for proper absorption

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition