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Notably, a randomized controlled trial in individuals with severe mental illness treated with clozapine or olanzapine reported that adjunctive liraglutide therapy led to significant reductions in body weight and HbA1c over 16 weeks, without destabilizing psychiatric symptoms (86)

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Participants received once-daily subcutaneous semaglutide at doses of 0.1 mg (80 patients), 0.2 mg (78 patients), 0.4 mg (82 patients), or placebo (80 patients)

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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 12(3), 288311

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